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. Author manuscript; available in PMC: 2011 Feb 9.
Published in final edited form as: Am J Hypertens. 2008 Sep 18;21(12):1284–1287. doi: 10.1038/ajh.2008.290

Figure 2.

Figure 2

(a) Blood glucose concentration during a 2-h glucose tolerance test in Mc3r+/+ and −/− mice fed the normal- (NSD) or high-sodium diet (HSD), and in Mc3r−/− mice fed the NSD but given either tap water or normal saline as drinking water. Mc3r−/− on the HSD and on the NSD with saline drinking water had a significantly greater area under the glucose-time curve than wild-type mice fed either diet or Mc3r−/− mice ingesting the NSD and drinking tap water. (b) Plasma insulin concentrations in the experiments shown in a. Mc3r−/− mice on the HSD or on the NSD plus saline drinking water were hyperinsulinemic throughout the glucose tolerance test compared to wild-type mice on either diet or knockouts on the NSD. (c) Blood glucose concentration during a 150 min insulin tolerance test. Blood glucose fell significantly less in Mc3r−/− mice fed the HSD compared to the other groups, suggesting blunted insulin-mediated glucose uptake. N = five mice per group; *values in Mc3r−/− mice on the HSD and on the NSD plus saline drinking water significantly different from the other three groups, P < 0.05 or greater by one-way analysis of variance.