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. Author manuscript; available in PMC: 2011 Feb 9.
Published in final edited form as: Curr Opin Pediatr. 2009 Apr;21(2):243–251. doi: 10.1097/mop.0b013e32832925cc

Figure 2. Example of possible mechanisms of gene-regulation by histone modifications.

Figure 2

Modifications under histone methylases (HMTs), histone acetyltransferases (HATs) and histone deacetylases (HDACs) control alter gene expression. Modifications may generate a structure that contains bromo- and chromo-domains allowing the recruitment of ATP-dependent chromatin remodelling factors to open the chromatin. Effects of histone modifications on gene expression is dependent on the specific position of the chemical modification on the histone subunit.