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Zn2+ supplementation promotes MMPs activation and increases BDNF levels in 3xTg-AD mice. (a) Gelatine zymography indicates that Zn2+ treatment induces a significant increase of MMP-2 and MMP-9 activation in 3xTg-AD mice brains. (b) BNDF immunoblotting reveals that Zn2+-treated 3xTg-AD mice show a fourfold increase in BDNF levels when compared with untreated animals. *P<0.05; **P<0.01. Error bars indicate mean values±S.E.M.
