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Schematic representation of the ADAM10-mediated processing mechanism of hFasL. At leat two different populations of hFasL were found in our study, one being inside the rafts, the other outside the rafts. Both population can interact with ADAM10, but only the palmitoylated raft localized one might optimally interacts with the receptor and mediates Fas-cell death. Only in this population FasL can be processed; a procedure which downregulates Fas-mediated cell death on the target cell
