Table 3.
rs13306560 and clinic BP in the GRAPHIC Study and validation cohorts
Study | Informative subjects |
Minor (coded) allele |
clinic SBP | clinic DBP | ||
---|---|---|---|---|---|---|
β (SE) | P-value | β (SE) | P-value | |||
GRAPHIC | 2,020 * | A | −3.07 (1.06) | 0.0039 | −2.60 (0.68) | 0.0001 |
CoLaus † | 5,356 * | −1.20 (0.85) | 0.1569 | −1.16 (0.54) | 0.0322 | |
SCS | 753 * | −6.17 (3.01) | 0.0407 | −4.53 (1.74) | 0.0094 | |
Combined ‡ | 8,129 * | −2.12 (0.65) | 0.0011 | −1.87 (0.41) | 5.4×10−6 |
CoLaus – Swiss population-based study; SCS – Silesian Cardiovascular Study; β - individual β-coefficient; SE – standard error; P – values were obtained from tests adjusted for age, age2, sex, antihypertensive treatment and familial correlations (where appropriate)
number of subjects with available genotype and phenotype information
rs13306560 was imputed in the CoLaus cohort (r2hat=0.88)
based on inverse variance-weighted fixed effects meta-analysis; P-values of heterogeneity test were 0.1512 and 0.0744 for SBP and DBP, respectively