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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Curr Opin Biotechnol. 2010 Nov 1;22(1):17–25. doi: 10.1016/j.copbio.2010.10.001

Figure 3. Metabolome dynamics reveal a role for purine salvage in the yeast respiro-fermentative transition.

Figure 3

Using isotopic standards and LC-MS to quantitate purine salvage pathway intermediates, Walther et al. solved the long-standing mystery of counter-intuitive total adenosine phosphate (AXP) depletion following glucose addition to respiring yeast. AXP is shuttled through IMP and inosine to prevent AMP accumulation and associated impairment of growth by low adenylate energy charge.