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Clonal origination and evolution in myeloproliferative neoplasms (MPNs). PV, polycythemia vera; ET, essential thrombocythemia; PMF, primary myelofibrosis; CML, chronic myelogenous leukemia; AML, acute myeloid leukemia; JAK2, Janus kinase 2; MPL, thrombopoietin receptor; TET2, TET oncogene family member 2; ASXL1, Additional Sex Combs-Like 1; CBL, Casitas B-lineage Lymphoma proto-oncogene; IDH, isocitrate dehydrogenase; IKZF1, IKAROS family zink finger 1.
