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. Author manuscript; available in PMC: 2012 Mar 15.
Published in final edited form as: Neuroimage. 2010 Dec 23;55(2):622–628. doi: 10.1016/j.neuroimage.2010.12.048

Figure 2.

Figure 2

Effect of IP cocaine on the signal time course in cerebral (nucleus accumbens, open symbols) and in extra-cerebral tissue (muscle, closed symbols). Injection of 25 mg/kg P904 IV at t = −30 min (left arrow) yields a 62.5% signal drop in nucleus accumbens (4.06 mm3) and 69.1% signal drop in muscle (9.58 mm3) at TE = 9.5 ms. The second arrow indicates the IP injection of cocaine (30 mg/kg), which leads to a signal increase in the cerebral tissue corresponding to a CBV decrease. The error bars show the standard deviation of the signal within the ROI in a single mouse. This is a typical signal time course prior to detrending.