Table 1. Demographics of the Study Population.
Variable | Definite ARVD (n=11) |
Probable ARVD (n=10) |
Controls (n=11) |
---|---|---|---|
Age, years | 41.2 ± 14.2 | 34.9 ± 12.1 | 29.8 ± 6.7 |
Men, % | 63.6 | 30.0 | 54.5 |
Prior symptoms, % | |||
Presyncope/Syncope | 4 (36) | 6 (60) | 0 (0) |
Palpitation | 5 (45) | 7 (70) | 0 (0) |
Family history, % | |||
SCD < 35 years of age | 1 (9) | 3 (33) | 0 (0) |
ARVD by TFC | 2 (18) | 4 (40) | 0 (0) |
ARVD by HP evidence | 4 (36) | 2 (20) | 0 (0) |
Depolarization, % | |||
Abnormal SAECG | 8 (73) | 5 (50) | 0 (0) |
Epsilon wave | 1 (9) | 0 (0) | 0 (0) |
T wave inversions, % | |||
Beyond V1 | 8 (73) | 4 (40) | 0 (0) |
Beyond V2 | 5 (45) | 3 (30) | 0 (0) |
Incomplete RBBB | 0 | 3 (30) | 0 (0) |
Complete RBBB | 0 | 0 (0) | 0 (0) |
Arrhythmia, % | |||
> 1000 PVCs on a 24-hour Holter monitor* | 7 (64) | 0 (0) | 0 (0) |
LBBB type VT | 4 (36) | 3 (30) | 0 (0) |
Structural abnormalities on Echo, % | |||
Global RV dilatation | 8 (73) | 4 (50) | 0 (0) |
Impaired RV function* | 6 (55) | 1 (13) | 0 (0) |
RV wall motion abnormalities | 1 (9) | 0 (0) | 0 (0) |
Global LV dilatation | 1 (9) | 0 (0) | 0 (0) |
Impaired RV function | 0 (0) | 0 (0) | 0 (0) |
Criteria points for ARVD diagnosis | |||
4+ | 6 (55) | 0 (0) | 0 (0) |
4 | 5 (45) | 0 (0) | 0 (0) |
3 | 0 (0) | 8 (80) | 0 (0) |
2 | 0 (0) | 2 (20) | 0 (0) |
1 | 0 (0) | 0 (0) | 0 (0) |
Values are expressed as n (%) or mean ± SD. Among those who did not meet the Task Force criteria, patients with a positive family history who had one additional minor criterion and patients without a family history with atleast 1 major or 2 minor criteria were classified as probable ARVD. Criteria points were calculated by adding the major (2 points each) and minor (1 point each) criteria fulfilled by the individual. The presence of 4 or more points is indicative of arrhythmogenic right ventricular dysplasia (ARVD) diagnosis by Task Force criteria.
p<0.05 for comparison between definite ARVD and probable ARVD patients.
SCD, sudden cardiac death; TFC: Task Force criteria; HP: histopathological; SAECG: signal-averaged ECG; RBBB: right bundle branch block; LBBB: left bundle branch block; VT: ventricular tachycardia