Table 1.
List of selected Leishmania actin-interacting proteins (AIPs) that are seemingly homologous to the phagosome proteins, as described by Garin et al. (2001). The proteins are presented with respective sequence ID (as on GeneDB), length (in number of amino acids), predicted molecular weight and isoelectric point (pI).
| Protein | Organism | Accession number | MW (kDa) | pI | Amino acids |
| Prohibitin | L.braziliensis | LbrM34.0070/LbrM16.1230 | 32.2/30.2 | 10.0/8.3 | 292/268 |
| L. infantum | LinJ16.1700/ LinJ35.0170 | 30.2/32.3 | 8.3/9.9 | 268/292 | |
| L. major | LmjF35.0070/ LmjF16.1610 | 32.3/30.2 | 9.9/8.3 | 292/268 | |
| RAB2 | L.braziliensis | LbrM30.1540 | 25.6 | 8.3 | 235 |
| L. infantum | LinJ30.2050 | 25.6 | 7.3 | 235 | |
| L. major | LmjF30.1710 | 25.6 | 7.3 | 235 | |
| RAB7 | L.braziliensis | LbrM18.0760/ LbrM10.0880 | 24.0/24.6 | 5.3/5.0 | 223/221 |
| L. infantum | LinJ10.1520 | 24.9 | 5.4 | 222 | |
| L. major | LmjF10.1170/ LmjF18.0890 | 24.7/24.1 | 5.7/5.1 | 221/223 | |
| RAB11B | L.braziliensis | LbrM32.1770 | 24.8 | 6.6 | 219 |
| L. infantum | LinJ32.2250 | 25.2 | 7.1 | 224 | |
| L. major | LmjF32.1840 | 25.2 | 7.1 | 224 | |
| Stomatin | L.braziliensis | LbrM05.0940 | 40.2 | 8.6 | 358 |
| L. infantum | LinJ05.1050 | 39.6 | 7.8 | 357 | |
| L. major | LmjF05.1040 | 39.7 | 8.3 | 357 | |
| Ubiquitin C | L.braziliensis | LM24.42/ LbrM25.0230 | 34.5/25.1 | 4.7/5.3 | 307/233 |
| LbrM32.0660 | 26.2 | 4.5 | 233 | ||
| L. infantum | LM24.42/ LinJ32.0850 | 34.3/26.3 | 4.9/4.3 | 307/234 | |
| LinJ25.0190 | 25.1 | 4.7 | 233 | ||
| L. major | LM24.42 / LmjF32.0700 | 34.4/26.4 | 4.8/4.4 | 307/234 | |
| Ubiquitin C | L.major | LmjF25.0190 | 25.1 | 4.9 | 233 |
| 14-3-3 | L.braziliensis | LbrM35_V2.3430/LbrM11_V2.0040 | 29.6/29.0 | 4.6/4.9 | 258/253 |
| L.infantum | LinJ36_V3.3360/ LinJ11_V3.0350 | 29.7/29.2 | 4.6/4.9 | 258/253 | |
| L.major | LmjF36.3210/ LmjF11.0350 | 29.6/29.1 | 4.6/5.0 | 258/253 | |
| ARP3 | L.braziliensis | LbrM15_V2.1360 | 38.1 | 5.4 | 348 |
| L.infantum | LinJ15_V3.1410 | 43.7 | 6.1 | 405 | |
| L.major | LmjF15.1360 | 43.7 | 5.9 | 405 | |
| Ash | L.infantum | LinJ30_V3.3620 | 18.6 | 5.7 | 162 |
| L.major | LmjF30.3560 | 18.5 | 6.1 | 162 | |
| L.braziliensis | LbrM30_V2.3590 | 18.5 | 6.9 | 162 | |
| Calreticulin | L.infantum | LinJ31_V3.2670 | 45.0 | 4.4 | 400 |
| L.major | LmjF31.2600 | 45.0 | 4.4 | 400 | |
| L.braziliensis | LbrM31_V2.2940 | 48.4 | 4.1 | 422 | |
| Cathepsin L | L.major | LmjF08.1030/ LmjF08.1040 | 48.0/37.7 | 7.6/7.1 | 443/348 |
| LmjF08.1010/ LmjF08.1020 | 37.9/37.7 | 7.3/6.7 | 348/348 | ||
| LmjF08.1050/ LmjF08.1060 | 37.8/48.0 | 6.7/7.6 | 348/443 | ||
| LmjF08.1070/ LmjF08.1080 | 37.8/48.0 | 6.7/7.6 | 348/443 | ||
| L.infantum | LinJ08_V3.0960/ LinJ08_V3.0950 | 47.9/41.3 | 7.2/7.5 | 443/381 | |
| L.braziliensis | LbrM08_V2.0810/ LbrM08_V2.0820 | 47.9/47.9 | 6.0/7.1 | 441/441 | |
| LbrM08_V2.0830 | 47.9 | 6.7 | 441 | ||
| Coronin | L.infantum | LinJ23_V3.1400 | 56.2 | 7.2 | 510 |
| L.major | LmjF23.1165 | 56.6 | 6.6 | 510 | |
| L.braziliensis | LbrM23_V2.1260 | 57.0 | 6.9 | 510 | |
| Cytochrome P450 | L.braziliensis | LbrM20_V2.2920/LbrM34_V2.2490 | 61.7/91.3 | 7.8/8.0 | 546/832 |
| LbrM20_V2.2230/ LbrM27_V2.0100 | 68.4/67.2 | 6.2/8.9 | 624/592 | ||
| LbrM30_V2.3580 | 58.0 | 7.3 | 509 | ||
| L.infantum | LinJ35_V3.2600/ LinJ34_V3.3110 | 91.1/61.3 | 8.0/6.7 | 832/546 | |
| LinJ34_V3.3610/ LinJ34_V3.2500 | 22.8/67.9 | 10.1/5.6 | 197/624 | ||
| LinJ27_V3.0090 | 66.7 | 8.6 | 592 | ||
| L.major | LmjF27.0090/ LmjF35.2560 | 68.5/90.9 | 8.1/7.9 | 606/831 | |
| LmjF34.3330/ LmjF30.3550 | 59.9/58.0 | 7.6/7.1 | 533/508 | ||
| LmjF34.2670 | 68.0 | 6.1 | 624 | ||
| HSP-60 | L.braziliensis | LbrM32_V2.2030/ LbrM30_V2.2790 | 64.3/58.2 | 6.0/5.4 | 594/539 |
| LbrM35_V2.2240/ LbrM35_V2.2250 | 60.2/59.5 | 5.3/5.1 | 564/562 | ||
| L. infantum | LinJ32_V3.1940/ LinJ36_V3.2130 | 64.3/60.5 | 6.4/5.1 | 594/566 | |
| LinJ36_V3.2140/ LinJ30_V3.2830 | 59.3/58.1 | 5.1/5.2 | 562/538 | ||
| L. major | LmjF32.1850/ LmjF36.2020 | 64.3/60.1 | 6.3/5.2 | 594/565 | |
| LmjF36.2030/ LmjF30.2820 | 59.3/58.0 | 5.1/5.3 | 562/538 | ||
| Prohibitin | L.braziliensis | LbrM34.0070/LbrM16.1230 | 32.2/30.2 | 10.0/8.3 | 292/268 |
| L. infantum | LinJ16.1700/ LinJ35.0170 | 30.2/32.3 | 8.3/9.9 | 268/292 | |
| L. major | LmjF35.0070/ LmjF16.1610 | 32.3/30.2 | 9.9/8.3 | 292/268 | |
| RAB2 | L.braziliensis | LbrM30.1540 | 25.6 | 8.3 | 235 |
| L. infantum | LinJ30.2050 | 25.6 | 7.3 | 235 | |
| L. major | LmjF30.1710 | 25.6 | 7.3 | 235 | |
| RAB7 | L.braziliensis | LbrM18.0760/ LbrM10.0880 | 24.0/24.6 | 5.3/5.0 | 223/221 |
| L. infantum | LinJ10.1520 | 24.9 | 5.4 | 222 | |
| L. major | LmjF10.1170/ LmjF18.0890 | 24.7/24.1 | 5.7/5.1 | 221/223 | |
| RAB11B | L.braziliensis | LbrM32.1770 | 24.8 | 6.6 | 219 |
| L. infantum | LinJ32.2250 | 25.2 | 7.1 | 224 | |
| L. major | LmjF32.1840 | 25.2 | 7.1 | 224 | |
| Stomatin | L.braziliensis | LbrM05.0940 | 40.2 | 8.6 | 358 |
| L. infantum | LinJ05.1050 | 39.6 | 7.8 | 357 | |
| L. major | LmjF05.1040 | 39.7 | 8.3 | 357 | |
| Ubiquitin C | L.braziliensis | LM24.42/ LbrM25.0230 | 34.5/25.1 | 4.7/5.3 | 307/233 |
| LbrM32.0660 | 26.2 | 4.5 | 233 | ||
| L. infantum | LM24.42/ LinJ32.0850 | 34.3/26.3 | 4.9/4.3 | 307/234 | |
| LinJ25.0190 | 25.1 | 4.7 | 233 | ||
| L. major | LM24.42 / LmjF32.0700 | 34.4/26.4 | 4.8/4.4 | 307/234 | |
| Ubiquitin C | L.major | LmjF25.0190 | 25.1 | 4.9 | 233 |
| 14-3-3 | L.braziliensis | LbrM35_V2.3430/LbrM11_V2.0040 | 29.6/29.0 | 4.6/4.9 | 258/253 |
| L.infantum | LinJ36_V3.3360/ LinJ11_V3.0350 | 29.7/29.2 | 4.6/4.9 | 258/253 | |
| L.major | LmjF36.3210/ LmjF11.0350 | 29.6/29.1 | 4.6/5.0 | 258/253 | |
| ARP3 | L.braziliensis | LbrM15_V2.1360 | 38.1 | 5.4 | 348 |
| L.infantum | LinJ15_V3.1410 | 43.7 | 6.1 | 405 | |
| L.major | LmjF15.1360 | 43.7 | 5.9 | 405 | |
| Ash | L.infantum | LinJ30_V3.3620 | 18.6 | 5.7 | 162 |
| L.major | LmjF30.3560 | 18.5 | 6.1 | 162 | |
| L.braziliensis | LbrM30_V2.3590 | 18.5 | 6.9 | 162 | |
| Calreticulin | L.infantum | LinJ31_V3.2670 | 45.0 | 4.4 | 400 |
| L.major | LmjF31.2600 | 45.0 | 4.4 | 400 | |
| L.braziliensis | LbrM31_V2.2940 | 48.4 | 4.1 | 422 | |
| Cathepsin L | L.major | LmjF08.1030/ LmjF08.1040 | 48.0/37.7 | 7.6/7.1 | 443/348 |
| LmjF08.1010/ LmjF08.1020 | 37.9/37.7 | 7.3/6.7 | 348/348 | ||
| LmjF08.1050/ LmjF08.1060 | 37.8/48.0 | 6.7/7.6 | 348/443 | ||
| LmjF08.1070/ LmjF08.1080 | 37.8/48.0 | 6.7/7.6 | 348/443 | ||
| L.infantum | LinJ08_V3.0960/ LinJ08_V3.0950 | 47.9/41.3 | 7.2/7.5 | 443/381 | |
| L.braziliensis | LbrM08_V2.0810/ LbrM08_V2.0820 | 47.9/47.9 | 6.0/7.1 | 441/441 | |
| LbrM08_V2.0830 | 47.9 | 6.7 | 441 | ||
| Coronin | L.infantum | LinJ23_V3.1400 | 56.2 | 7.2 | 510 |
| L.major | LmjF23.1165 | 56.6 | 6.6 | 510 | |
| L.braziliensis | LbrM23_V2.1260 | 57.0 | 6.9 | 510 | |
| Cytochrome P450 | L.braziliensis | LbrM20_V2.2920/LbrM34_V2.2490 | 61.7/91.3 | 7.8/8.0 | 546/832 |
| LbrM20_V2.2230/ LbrM27_V2.0100 | 68.4/67.2 | 6.2/8.9 | 624/592 | ||
| LbrM30_V2.3580 | 58.0 | 7.3 | 509 | ||
| L.infantum | LinJ35_V3.2600/ LinJ34_V3.3110 | 91.1/61.3 | 8.0/6.7 | 832/546 | |
| LinJ34_V3.3610/ LinJ34_V3.2500 | 22.8/67.9 | 10.1/5.6 | 197/624 | ||
| LinJ27_V3.0090 | 66.7 | 8.6 | 592 | ||
| L.major | LmjF27.0090/ LmjF35.2560 | 68.5/90.9 | 8.1/7.9 | 606/831 | |
| LmjF34.3330/ LmjF30.3550 | 59.9/58.0 | 7.6/7.1 | 533/508 | ||
| LmjF34.2670 | 68.0 | 6.1 | 624 | ||
| HSP-60 | L.braziliensis | LbrM32_V2.2030/ LbrM30_V2.2790 | 64.3/58.2 | 6.0/5.4 | 594/539 |
| LbrM35_V2.2240/ LbrM35_V2.2250 | 60.2/59.5 | 5.3/5.1 | 564/562 | ||
| L. infantum | LinJ32_V3.1940/ LinJ36_V3.2130 | 64.3/60.5 | 6.4/5.1 | 594/566 | |
| LinJ36_V3.2140/ LinJ30_V3.2830 | 59.3/58.1 | 5.1/5.2 | 562/538 | ||
| L. major | LmjF32.1850/ LmjF36.2020 | 64.3/60.1 | 6.3/5.2 | 594/565 | |
| LmjF36.2030/ LmjF30.2820 | 59.3/58.0 | 5.1/5.3 | 562/538 |
*Predicted Molecular Weight and Isoeletric Point (pI).
14-3-3 proteins are a family of conserved regulatory molecules expressed in all eukaryotic cells. 14-3-3 proteins have the ability to bind a multitude of functionally diverse signaling proteins, including kinases, phosphatases, and transmembrane receptors, being considered evolved members of the Tetratricopeptide Repeat (TPR) superfamily.
*Predicted features and general scheme are the same as at GeneDB, including accession number / ID (Lmj = L. major; Lin = L. infantum; Lbr = L.braziliensis), according to the manuscript text.