Table 3.

Risk estimates and breast cancer history according to risk category in the 902 women who underwent genetic risk assessment.

	Estimated lifetime risk for breast cancer < 0.2 (n = 633)	Estimated lifetime risk for breast cancer ≥ 0.2 (n = 55)	Phenotype of breast cancer predisposition syndrome (n = 214)	p
Number of BC cases in family*	0.98 ± 0.67	1.45 ± 0.83	1.69 ± 1.14	< 0.001
Number of BC-affected generations*	0.92 ± 0.54	1.24 ± 0.55	1.29 ± 0.64	< 0.001
Average age (yr) at BC diagnosis in the family	46.6 ± 10.6	47.0 ± 11.4	46.6 ± 11.2	0.968
ELTR for BC
Using the Gail model**	10.2 ± 4.1	19.2 ± 5.1	12.3 ± 6.6	< 0.001
Using the Claus model*	10.2 ± 2.8	16.7 ± 7.8	13.9 ± 7.4	< 0.001
Using the Tyrer-Cuzick model**	9.8 ± 3.7	19.6 ± 6.2	12.4 ± 5.6	< 0.001
Prior probability of mutation in a BRCA gene
Mutation prevalence tables***	6.3 ± 3.8	6.7 ± 3.9	13.2 ± 13.0	< 0.001
Modified Couch model***	9.7 ± 4.3	10.3 ± 5.0	14.8 ± 10.6	< 0.001

The values are the mean ± SD. BC = breast cancer, BCPS = breast cancer predisposition syndrome, ELTR = estimated lifetime risk.

*The mean value of the group with a slightly increased risk was significantly lower than that of the other two groups.

**The mean values in all three groups differed significantly from each other.

***The mean value of the group that had criteria for breast cancer predisposition syndrome was significantly greater than that of the other two groups.

Note: The number of valid cases used in each of the ELTR and prior probability analyses was 878, 592 and 874 for the Gail, Claus and Tyrer-Cuzick models, respectively. For the mutation prevalence tables and the modified Couch model, 890 and 874 valid cases were used, respectively.