Table 3.

Association studies of bronchial and emphysematous COPD types with annual FEV1 decline (ΔFEV₁), cigarette smoking, body mass index (BMI) and SERPINA1 genotypes.

Type/Class	COPD phenotype		p
	CB	CLE+PEL
ΔFEV1 (ml/year)	171 ± 137	232 ± 239	0.243a
Cumulative cigarette consumption	59.41 ± 29.22	51.97 ± 28.68	0.230a
BMI (kg/m2)	24.33 ± 3.70	22.77 ± 5.21	0.117a
M1Ala	0.41	0.53
No M1Ala	0.58	0.47	0.306b
M2	0.45	0.45
No M2	0.54	0.54	1b
M3	0.39	0.53
No M3	0.60	0.46	0.184b

CB: Chronic Bronchitis; CLE: Centrolobular Emphysema; PLE: Panlobular Emphysema; Cumulative cigarette consumption = number of packs smoked per day multiplied by years of consumption. M1Ala: heterozygous and homozygous for Ala213 allele; no M1Ala: homozygous for Val213 allele; M2: heterozygous and homozygous for His101allele; no M2: homozygous for Arg101 allele; M3: heterozygous and homozygous for Asp376 allele; no M3: homozygous for Glu376 allele.

^aStudent's t test; ^bPearson's χ² test.