Table 2.
GSTM1 and T1 genotypes in atopic asthma patients stratified by pertinent characteristics.
| Clinical features | n |
GSTM1 |
GSTT1 |
GSTM1/T1 |
||||||
| Present n (%) | Null n (%) | Present n (%) | Null n (%) | Both present n (%) | One null n (%) | Both null n (%) | ||||
| Median age at diagnosis | 86 | |||||||||
| ≤ 10 years | 51 | 23 (26.8) | 28 (32.5) | 42 (48.8) | 9 (10.5) | 19 (22.1) | 27 (31.4) | 5 (5.8) | ||
| > 10 years | 35 | 11 (12.8) | 24 (27.9) | 30 (34.9) | 5 (5.8) | 8 (9.3) | 25 (29.1) | 2 (2.3) | ||
| p value | 0.30 | 0.90 | reference | 0.18 | 0.96 | |||||
| Gender | 86 | |||||||||
| Male | 39 | 16 (18.7) | 23 (26.7) | 35 (40.7) | 4 (4.7) | 13 (15.2) | 25 (29.0) | 1 (1.2) | ||
| Female | 47 | 18 (20.9) | 29 (33.7) | 37 (43.0) | 10 (11.6) | 14 (16.2) | 27 (31.4) | 6 (7.0) | ||
| p value | 0.97 | 0.28 | reference | 0.99 | 0.23 | |||||
| Ethnic origin | 86 | |||||||||
| Caucasian | 79 | 30 (34.9) | 49 (56.9) | 66 (76.7) | 13 (15.1) | 23 (26.8) | 50 (58.0) | 6 (7.0) | ||
| Afro-American | 7 | 4 (4.7) | 3 (3.5) | 6 (7.0) | 1 (1.2) | 4 (4.7) | 2 (2.3) | 1 (1.2) | ||
| p value | 0.55 | 0.88 | reference | 0.19 | 0.97 | |||||
| Severity of disease | 86 | |||||||||
| Mild | 28 | 13 (15.2) | 15 (17.4) | 22 (25.6) | 6 (7.0) | 9 (10.5) | 17 (19.7) | 2 (2.3) | ||
| Moderate | 21 | 6 (7.0) | 15 (17.4) | 19 (22.1) | 2 (2.3) | 6 (7.0) | 13 (15.2) | 2 (2.3) | ||
| Severe | 37 | 15 (17.4) | 22 (25.6) | 31 (36.0) | 6 (7.0) | 12 (13.9) | 22 (25.6) | 3 (3.5) | ||
| p value | 0.44 | 0.53 | reference | 0.96 | 0.93 | |||||