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. Author manuscript; available in PMC: 2012 Jan 15.
Published in final edited form as: Dev Biol. 2010 Nov 10;349(2):483–493. doi: 10.1016/j.ydbio.2010.11.006

Fig. 2. alcama morphants have cartilage defects similar to the edn1 class of mutants.

Fig. 2

Flatmounts of mandibular and hyoid cartilage from 5 dpf alcian-blue stained larvae (A,C,E,G); corresponding schematics (B,D,F,H). The joint between Meckel's and palatoquadrate is fused in alcama morphants and furinA-/- and edn1-/- mutants. Similarly, the interhyal is absent in alcama morphants and furinA-/- mutants leading to a fusion of the ceratohyal and hyosymplectic cartilages. alcama morphants and furinA-/- mutants have misshapen Meckel's cartilage and ceratohyal, but edn1-/- mutants have the most severe defect with a lack of ceratohyal and severely misshapen Meckel's cartilage. DV joint regions are indicated with arrows in A and B. Fusions at joints are indicated with asterisks in (C-H). Cartilages are labeled as followed: pq (palatoquadrate), mc (Meckel's cartilage), hm (hyomandibula), ch (ceratohyal), sy (symplectic), and ih (interhyal). Scale bar: 50 μm.