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. Author manuscript; available in PMC: 2012 Jan 15.
Published in final edited form as: Dev Biol. 2010 Nov 10;349(2):483–493. doi: 10.1016/j.ydbio.2010.11.006

Fig. 7. alcama and nadl1.1 interact during cartilage formation.

Fig. 7

(A) Lateral view of a 30 hpf WT larva stained with Zn-5 antibody (Fast Red) and anti-sense nadl1.1 RNA (Fluorescein), revealing that nadl1.1 is expressed in the NC adjacent to alcama in the endoderm. The bar graphs display the percentage of 30 hpf edn1-/- (B) and WT (C) larvae with dlx5a staining after the indicated injections. (B) shows that nadl1.1 is required for alcama rescue of dlx5a expression in edn1-/- mutants (p-value < 0.0001 by Fishers exact test). (C) and (D) show that alcama and nadl1.1 interact during dlx5a expression and cartilage morphogenesis. (D) Bar graph displaying the percentage of 5 dpf larvae with affected cartilage after the indicated injections (p-value < 0.0001 by χ2 analysis). n indicates the number of experiments and N the total number of larvae. Scale bar: 50 μm.