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. Author manuscript; available in PMC: 2012 Jan 15.
Published in final edited form as: Dev Biol. 2010 Nov 10;349(2):483–493. doi: 10.1016/j.ydbio.2010.11.006

Fig. 8. Model demonstrating how Alcama mediates Edn1 signaling and NC differentiation.

Fig. 8

Previous data has supported the model that Edn1 peptide binds to its G-protein coupled receptor on NC to turn on transcription of NC genes. We propose a parallel pathway by which Edn1 signaling stabilizes Alcama protein in endodermal cells. Alcama, in turn, binds to Nadl1.1 in NC and regulates NC differentiation.