Table 5.

Data collection at Clinic visits (Baseline and Week 8): Cognitive data for 'Thinking' processes

Domain	Sub-domain	Task	Measurea	Time (minutes)	Method	Administrator
Thinking	Response Speed	Motor Tapping	Number of Taps	30	Touchscreen	Part.
			Variability of Pause between Taps
	Impulsivity	Go-NoGo	Reaction Time	30	Touchscreen	Part.
			Variability of Reaction Time
			False 'alarm' errors
	Attention-Concentration	Continuous Performance Test	Reaction Time	30	Touchscreen	Part,
			False 'alarm' errors
			False 'miss' errors
	Information Processing Efficiency	Switching of Attention	Completion Time (digits + letters)	30	Touchscreen	Part.
			Average Connection Time (digits + letters)
			Errors (digits+letters)
		Verbal Interference	Part 2- Part 1 Errors	30	Touchscreen	Part.
			Part 2- Part 1 Reaction Time
		Choice Reaction Time	Reaction Time	30	Touchscreen	Part.
	Memory	Digit Span	Recall Span	30	Touchscreen	Part.
			Trials correct
		Memory Recognition	Total immediate recall trials 1-4	30	Touchscreen	Part.
			Learning rate trials 1-4
			Delayed recall trial 7
	Executive Function	Maze	Completion Time	30	Touchscreen	Part.
			Path Learning Time
			Overrun Errors
			Total Errors

^a Hypothesized contrast is Treatment Responders < Non-Responders

(with a common direction of reduction for poorer accuracy, reduced variability, and slowed reaction time)

Abbreviations:

Part. = Participant