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. 2011 Feb 9;6(2):e14671. doi: 10.1371/journal.pone.0014671

Figure 4. Kisspeptin induced oedema presents with a pallor ring at injection site in the dorsal skin.

Figure 4

Female CD1 mice were anaesthetised, injected with Evans Blue i.v. and treated intradermally in the dorsal skin with 10pmol CGRP, 300pmol substance P (SP), 10nmol Kp-10 (K10), 10nmol Kp-10 +300pmol substance P (K + SP), 300pmol substance P +10pmol CGRP (SP + CGRP) or 10nmol Kp-10 +10pmol CGRP (K + CGRP). Plasma extravasation was allowed to continue for 30 minutes. Mice were killed, the dorsal skin removed and photographed. Pallor ring present in Kp-10 mediated oedema, but not under other conditions, is indicated.