Table 1. Kisspeptin-10 mediated oedema formation is visible 7.5 minutes post-injection.

	Time (Minutes)
KP (nmol/site)	7.5	15	30
0.3	5.20±1.74	23.5±8.84	0±0
1	20.8±4.75**	21.7±5.30	7.75±3.50
3	39.2±4.26***	43.7±10.7***	20.5±8.13
10	38.4±10.5***	47.8±6.41***	45.5±11.7*

Female CD1 mice were anaesthetised, injected with Evans Blue i.v. and treated intradermally with 0.3–10nmol Kp-10 (KP) in the dorsal skin for 7.5, 15 or 30 minutes. Mice were killed, the dorsal skin removed and the area of oedema measured. Results are shown as mean area (mm²) ± SEM (3 s.f.). 7.5, 15 and 30 minute treatment groups consisted of N = 5, N = 6 and N = 4 respectively.

^* = p≤0.05,

^** = p≤0.01,

^*** = p≤0.001 compared to vehicle controls as assessed by one way ANOVA followed by a Dunnet's post test.