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. 2011 Feb 9;6(2):e16732. doi: 10.1371/journal.pone.0016732

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MacIntyre et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Analysis of the metabolic profiles of CMp11 and CMp18 media by PCA revealed disparate metabolic profiles as evident in the score plot. (B) Examination of the corresponding loadings plot indicated CMp18 media contained characteristically higher concentrations of glucose and glutamine and comparably lower concentrations of lactate and alanine highlighting reduced metabolic activity of the passage 18 HFFs.