Table 6. Haplotype association results.
| A | |||||||||
| Haplotype | Frequency | Association test | |||||||
| Campora | Gioi | Cardile | Campora | Gioi | Cardile | ||||
| Z | p-value* | Z | p-value | Z | p-value | ||||
| CTC | 0.383 | 0.208 | 0.176 | 1.75 | 0.080 | −0.20 | 0.844 | −0.16 | 0.871 |
| CCC | 0.381 | 0.575 | 0.566 | −1.08 | 0.280 | −1.03 | 0.304 | 0.79 | 0.430 |
| CCT | 0.133 | 0.127 | 0.161 | −2.06 | 0.039 | 1.16 | 0.244 | −0.31 | 0.758 |
| TCC | 0.049 | 0.062 | 0.064 | 0.44 | 0.662 | −0.21 | 0.831 | −0.80 | 0.424 |
| TTC | 0.027 | 0.017 | 0.028 | 2.79 | 0.005 | 0.12 | 0.901 | −0.50 | 0.616 |
| TCT | 0.026 | 0.001 | 0.005 | −0.44 | 0.657 | - | - | - | - |
| TTT | 0.001 | 0 | 0 | - | - | - | - | - | - |
| CTT | 0 | 0.010 | 0.001 | - | - | - | - | - | - |
| *p-value threshold corrected for multiple testing = 0.008. | |||||||||
Associations between the rs25648, rs3025020 and rs3025039 haplotypes and the VEGF serum levels (A) and associations between the rs25648, rs3025020, rs3025039 and rs41282644 haplotypes and the VEGF serum levels (B) in the population samples of Campora, Gioi and Cardile are presented. Only the haplotypes with a frequency>1% were tested.