Figure 1. Nifedipine infusion does not affect blood pressure.
Mice were subjected to either sham or transverse aortic constriction (TAC) operation in the presence of continuous infusion of nifedipine (10mg/kg/day) or vehicle by osmotic pump for two weeks. Post constriction mean arterial pressure (MAP) (A) and pressure gradient (B) were measured, using a catheter under anesthesia. Values are mean ± SEM. n=4 in each group. (C) Representative simultaneous recording of blood pressure at ascending aorta and abdominal aorta from animals subjected to TAC in the presence ((+) Nife) or absence ((−) Nife) of nifedipine.