Figure 4. Nifedipine inhibits TAC induced cardiac dysfunction.
Mice were subjected to either sham or transverse aortic constriction (TAC) operation in the presence of continuous infusion of nifedipine (10mg/kg/day) or vehicle by osmotic pump for two weeks. (A) Postmortem measurement of lung weight/body weight (Lung W/BW, mg/g). (B) Echocardiographic analysis was conducted under anesthesia to evaluate ejection fraction (%), an index of LV systolic function. Values are mean ± SEM. n=6 in each group. *p<0.05.