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. Author manuscript; available in PMC: 2012 Feb 9.
Published in final edited form as: Nano Lett. 2011 Jan 6;11(2):814–819. doi: 10.1021/nl104141g

FIGURE 1.

FIGURE 1

Schematic illustration of the process of triple-loading. First, we introduced RGD4C and Cy5.5 onto the surfaces of two sets of ferritins, via genetic and chemical means. These two ferritins were then mixed and broken down into subunits at pH=2, and incubated with 64CuCl2 to achieve radiolabeling. The pH was then adjusted back to 7.4 to facilitate the reformation of nanostructures. The reconstituted chimeric ferritin nanocages have both RGD4C and Cy5.5 on their surfaces and 64Cu loaded in their cavities.