Table 3.
Baseline demographics and clinical outcome in 39 patients with infective endocarditis stratified by the GPIIIa PlA1/A2 platelet receptor genotype.
| GPIIIa PlA1/A2 genotype |
P valuea | ||
|---|---|---|---|
| A1/A1, n = 29 | A1/A2, n = 10 | ||
| Age (y) | 56 ± 17 | 56 ± 17 | 0.949 |
| Male (%) | 22 (76) | 8 (80) | 1.000 |
| Native valve (%) | 20 (69) | 6 (60) | 0.704 |
| Valvular heart disease (%) | 8 (28) | 5 (50) | 0.254 |
| Previous infective endocarditis (%) | 2 (7) | 3 (30) | 0.096 |
| Intravenous drug abuser (%) | 3 (10) | 1 (10) | 1.000 |
| Affected valve (%) | |||
| Mitral | 11 (38) | 4 (40) | 0.524 |
| Aortic | 10 (35) | 3 (30) | |
| Mitral + aortic | 5 (17) | 1 (10) | |
| Tricuspid ± mitral/aortic | 3 (10) | 1 (10) | |
| Pulmonary | 0 | 1 (10) | |
| Presence of vegetations (%) | 22 (76) | 8 (80) | 1.000 |
| Vegetation length, mmb | 14 ± 5 | 20 ± 12 | 0.166 |
| Vegetation width, mmb | 9 ± 4 | 9 ± 3 | 0.946 |
| Organism (%) | |||
| Streptococci | 13 (45) | 2 (20) | 0.030 |
| Staphylococci | 10 (35) | 1 (10) | |
| Streptococci + staphylococci | 2 (7) | 0 (0) | |
| Enterococci | 1 (3) | 1 (10) | |
| Other | 2 (7) | 5 (50) | |
| Culture negative | 1 (3) | 1 (10) | |
| Surgery (%) | 18 (62) | 7 (70) | 0.721 |
| Embolic phenomena (%) | 8 (28) | 7 (70) | 0.027 |
| Heart failure (%) | 10 (34) | 1 (10) | 0.228 |
| Death (%) | 6 (21) | 3 (30) | 0.669 |
| Composite clinical end-point (%)c | 22 (73%) | 8 (80%) | 1.000 |
a
P values were determined using the Mann–Whitney U test for numerical variables, and Fisher’s exact test or the chi-squared test for categorical variables. Data for the one PlA2/A2 subject are not depicted and were excluded from all analyses.
b
Data on vegetation characteristics were available for 29 of the 30 subjects with vegetations.
c
The clinical end-point represents a composite of embolism, heart failure, need for surgery and mortality.