Table 4.
Baseline demographics and clinical outcome in 40 patients with infective endocarditis stratified by the FcγRIIa H131R platelet receptor polymorphism.
| FcγRIIa H131R genotype |
P valuea | |||
|---|---|---|---|---|
| H/H, n = 11 | H/R, n = 19 | R/R, n = 10 | ||
| Age (y) | 56 ± 13 | 59 ± 18 | 49 ± 21 | 0.470 |
| Male (%) | 6 (55) | 15 (79) | 9 (90) | 0.149 |
| Native valve (%) | 8 (73) | 10 (53) | 8 (80) | 0.279 |
| Valvular heart disease (%) | 7 (64) | 5 (26) | 2 (20) | 0.061 |
| Previous infective endocarditis (%) | 3 (27) | 2 (11) | 1 (10) | 0.408 |
| Intravenous drug abuser (%) | 0 | 3 (16) | 1 (10) | 0.381 |
| Affected valve (%) | ||||
| Mitral | 5 (45) | 7 (37) | 4 (40) | 0.005 |
| Aortic | 0 | 11 (58) | 2 (20) | |
| Mitral + aortic | 5 (45) | 0 | 1 (10) | |
| Tricuspid ± mitral/aortic | 1 (10) | 1 (5) | 2 (20) | |
| Pulmonary | 0 | 0 | 1 (10) | |
| Presence of vegetations (%) | 9 (82) | 14 (74) | 8 (80) | 0.856 |
| Vegetation length, mmb | 21 ± 14 | 13 ± 5 | 16 ± 7 | 0.166 |
| Vegetation width, mmb | 8 ± 2 | 8 ± 4 | 10 ± 5 | 0.946 |
| Organism (%) | ||||
| Streptococci | 4 (37) | 6 (32) | 5 (50) | 0.545 |
| Staphylococci | 2 (18) | 6 (32) | 3 (30) | |
| Streptococci + staphylococci | 1 (9) | 1 (5) | 0 | |
| Enterococci | 2 (18) | 0 | 0 | |
| Other | 1 (9) | 4 (21) | 2 (20) | |
| Culture negative | 1 (9) | 2 (10) | 0 | |
| Surgery (%) | 10 (91) | 7 (37) | 8 (80) | 0.005 |
| Embolic phenomena (%) | 2 (18) | 8 (42) | 5 (50) | 0.274 |
| Heart failure (%) | 6 (55) | 6 (32) | 0 | 0.024 |
| Death (%) | 4 (36) | 5 (26) | 0 | 0.118 |
| Composite clinical end-point (%)c | 10 (91%) | 12 (63%) | 8 (80%) | 0.219 |
a
P values were determined using the Kruskal–Wallis test with Mann–Whitney U correction for numerical variables and the chi-squared test for categorical variables.
b
Data on vegetation characteristics were available for 30 of 31 subjects with vegetations.
c
The clinical end-point represents a composite of embolism, heart failure, need for surgery and mortality.