Fig. 2.

One-year change of joint space narrowing (JSN) scores in tocilizumab-treated rheumatoid arthritis (RA) patients with risk factors for developing JSN. Score changes were analyzed for individual risk factors (a uCTX, b uPYD/DPD, c BMI, d JSN) at baseline. Results are expressed as median (line across boxes), 25–75% interquartile range (boxes), mean (cross symbol in boxes), standard deviation (SD) (vertical line across top of the box), and standard error (vertical line across bottom of the box). The filled circles represent individual values over SD values. Differences in change in JSN scores were compared by the Wilcoxon rank sum test. uPYD/DPD urinary pyridinoline/deoxypyridinoline ratio, uCTX-II urinary C-terminal telopeptide of type II collagen, BMI body mass index, TCZ tocilizumab