Table 3.
IC50 values (μM) of the [Ru(tpy)L1L2 n−](2−n)+ complexes (1a, 1b, 1c, 1d, 1e) and the dinuclear complex [Ru(apy)(tpy)]2[μ-H2N(CH2)6NH2](ClO4)4 (1f) after a 48-h treatment in some selected cell lines
| Compound tested | A2780 | A2780R | L1210/0 | L1210/2 |
|---|---|---|---|---|
| [Ru(apy)(tpy)Cl](ClO4) (1a) | 23 | 25 | 100 | 56 |
| [Ru(apy)(tpy)(H2O)](ClO4)2·2H2O (1b) | 11 | 30 | 80 | 97 |
| [Ru(apy)(tpy)(CH3CN)] (ClO4)2 (1c) | 31 | 28 | 70 | 40 |
| [Ru(azpy)(tpy)Cl]Cl·5H2O (1d) | 19 | 42 | 42 | 26 |
| [Ru(impy)(tpy)Cl] (ClO4) (1e) | >100 | 62 | >100 | >100 |
| [Ru(apy)(tpy)]2[μ-H2N(CH2)6NH2] (ClO4)4 (1f) | 33 | 28 | >100 | >100 |
| α-[Ru(azpy)2Cl2] | 0.1 | 0.2 | 0.1 | 0.2 |
| Cisplatin | 6 | 25 | 2 | 24 |
α-[Ru(azpy)2Cl2] and cisplatin have been included as reference compounds