Table I.

Demographic and clinical characteristics at enrollment of TESAOD participants according to their lung function at enrollment. Vital status as of January 2005 is also presented. N is 2048, unless otherwise specified.

	LUNG FUNCTION AT ENROLLMENT
	Normal (N = 1505)	Restrictive Spirometric Pattern (N = 249)	Obstructive Spirometric Pattern (N = 294)	P value*
Age in years: mean ± SD	46 ± 17	60 ± 15	60 ± 15	N/A
Sex: % female	56.3	67.1	46.9 ^ ‡	<0.001
Obesity, (n = 1978): % with BMI ≥ 30 Kg/m2	6.8	13.6 ^	6.4 ‡	0.004
Years of formal education: % with > 12 years	45.8	37.8	32.0	0.27
Ever smoking (n = 2046): % with ≥ 1 pack-year	53.9	50.6	77.1 ^ ‡	<0.001
Pack-Years (n = 1163): geometric mean among ever smokers	14.1	22.5	28.9 ^	0.006
Physician confirmed asthma (n = 2046): positive %	8.2	14.1 ^	23.5 ^ ‡	<0.001
Allergy skin tests (n = 2012): positive %	39.7	25.9	31.6	0.28
Eosinophilia (n = 1542): positive %	7.4	9.6	12.8 ^	0.01
Total serum IgE in IU/ml (n = 1836): geometric mean	27.5	21.5	37.8 ^ ‡	<0.001
Chronic Cough and Phlegm: % positive	7.7	13.7 ^	31.0 ^ ‡	<0.001
Shortness of Breath with Wheezing (n = 2043): % positive	16.9	27.7 ^	42.8 ^ ‡	<0.001
≥ Grade 2 on the Modified MRC Dyspnea Scale^^ (n = 2038): %positive	9.5	24.0 ^	34.9 ^ ‡	<0.001
Ever Pneumonia: % positive	23.0	40.6 ^	39.5 ^	<0.001
Ever “Heart Trouble”: % positive	13.8	26.1	20.7	0.36
Ever stroke: % positive	1.1	6.0 ^	3.1	0.05
Diabetes: % positive	3.0	7.2	4.4	0.29
Deceased as of January 2005: % deceased	46.3	82.7	84.0	N/A

Statistical comparisons are completed across the three groups after adjustment for age (p value reported in the last column) as well as between pairs after adjustment for age and Bonferroni correction.

^*P value for the comparison across the three groups after adjustment for age.

^{^}Significantly different from Normal after adjustment for age and Bonferroni correction.

^‡Significantly different from Restrictive Spirometric Pattern after adjustment for age and Bonferroni correction.