Table 2.
Relationships between serum lipids and APOE, APOB and LDLR polymorphisms in individuals with xanthelasma. No statistically significant differences were found.
| Polymorphisms | Lipids (mg/dL)
|
|||||
| TC | HDL-c | LDL-c | VLDL-c | TG | ||
| APOE HhaI | E2E3 (7) | 204.9 ± 40.2 | 46.3 ± 6.1 | 131.7 ± 42.4 | 26.9 ± 4.0 | 134.3 ± 19.5 |
| E3E3 (34) | 204.8 ± 23.6 | 46.5 ± 8.0 | 125.6 ± 26.6 | 32.6 ± 6.9 | 162.5 ± 34.4 | |
| E3E4 (9) | 204.1 ± 14.0 | 47.7 ± 10.1 | 122.9 ± 13.6 | 33.6 ± 7.2 | 167.4 ± 36.2 | |
| P | 0.422 | 0.893 | 0.801 | 0.073 | 0.069 | |
| Pc | 1.000 | 1.000 | 1.000 | 0.219 | 0.207 | |
| APOB XbaI | X+X+ (11) | 208.0 ± 22.4 | 49.1 ± 7.8 | 126.4 ± 22.0 | 32.5 ± 6.4 | 162.6 ± 32.2 |
| X+X- (57) | 203.0 ± 25.4 | 47.5 ± 7.5 | 126.3 ± 24.5 | 28.9 ± 8.7 | 144.1 ± 43.3 | |
| X-X- (31) | 203.8 ± 31.6 | 45.4 ± 9.5 | 126.6 ± 31.4 | 31.2 ± 8.4 | 155.5 ± 41.9 | |
| P | 0.759 | 0.343 | 0.915 | 0.079 | 0.071 | |
| Pc | 1.000 | 1.000 | 1.000 | 0.237 | 0.213 | |
| APOB Ins/Del | II (37) | 206.1 ± 32.2 | 47.3 ± 9.7 | 128.1 ± 30.8 | 28.7 ± 7.8 | 143.1 ± 38.8 |
| ID (50) | 202.3 ± 23.4 | 46.1 ± 7.2 | 125.7 ± 23.5 | 31.2 ± 9.1 | 155.4 ± 45.5 | |
| DD (12) | 203.3 ± 24.6 | 49.7 ± 7.5 | 124.3 ± 24.9 | 29.3 ± 6.9 | 146.3 ± 35.1 | |
| P | 0.702 | 0.461 | 0.820 | 0.398 | 0.432 | |
| Pc | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | |
| LDLR AvaII | A+A+ (3) | 230.7 ± 54.9 | 41.7 ± 5.7 | 156.3 ± 60.1 | 32.7 ± 5.0 | 163.0 ± 24.6 |
| A+A- (26) | 203.0 ± 21.9 | 45.7 ± 8.5 | 125.5 ± 24.0 | 31.7 ± 7.9 | 158.0 ± 39.2 | |
| A-A- (21) | 203.1 ± 21.7 | 48.7 ± 7.5 | 122.2 ± 23.9 | 32.2 ± 5.9 | 160.8 ± 29.4 | |
| P | 0.409 | 0.169 | 0.403 | 0.906 | 0.893 | |
| Pc | 1.000 | 0.507 | 1.000 | 1.000 | 1.000 | |
| LDLRHincII | H+H+ (35) | 198.3 ± 21.2 | 47.9 ± 8.1 | 118.9 ± 20.2 | 31.5 ± 8.4 | 157.4 ± 41.9 |
| H+H- (43) | 208.2 ± 27.5 | 46.5 ± 8.9 | 131.5 ± 27.3 | 29.1 ± 7.6 | 145.3 ± 38.1 | |
| H-H- (8) | 207.9 ± 45.7 | 47.0 ± 7.6 | 133.6 ± 43.7 | 27.3 ± 13.5 | 136.0 ± 67.6 | |
| P | 0.276 | 0.687 | 0.191 | 0.713 | 0.683 | |
| Pc | 0.828 | 1.000 | 0.573 | 1.000 | 1.000 | |
Number of individuals between parenthesis. TC, total cholesterol; HDL-c, high-density lipoprotein cholesterol; LDL-c, low-density lipoprotein cholesterol; VLDL-c, very low-density lipoprotein cholesterol; TG, triglycerides. +/- indicates the presence/absence of a restriction site. Ins/Del indicates insertion/deletion. Data are reported as mean±SD and compared by the Mann-Whitney test. Values for APOE genotypes were compared by the Kruskal-Wallis test. Pc = probability-value in reference to Bonferroni correction.