Table 3.
Relationships between serum lipids and APOE, APOB and LDLR polymorphisms in the control group. No statistically significant differences were found.
| Polymorphisms | Lipids (mg/dL)
|
|||||
| TC | HDL-c | LDL-c | VLDL-c | TG | ||
| APOE HhaI | E2E3 (4) | 186.5 ± 9.8 | 44.3 ± 4.6 | 108.3 ± 16.4 | 34.0 ± 2.7 | 169.3 ± 13.3 |
| E3E3 (63) | 206.5 ± 32.7 | 47.3 ± 7.5 | 126.2 ± 35.4 | 33.0 ± 6.6 | 164.7 ± 33.1 | |
| E3E4 (16) | 213.3 ± 36.3 | 45.8 ± 8.0 | 132.3 ± 39.5 | 35.1 ± 5.5 | 175.4 ± 27.4 | |
| P | 0.261 | 0.628 | 0.543 | 0.142 | 0.160 | |
| Pc | 0.783 | 1.000 | 1.000 | 0.426 | 0.480 | |
| APOB XbaI | X+X+ (12) | 206.3 ± 36.1 | 48.4 ± 6.8 | 122.8 ± 27.5 | 35.0 ± 11.4 | 174.2 ± 56.6 |
| X+X- (56) | 201.9 ± 30.1 | 47.2 ± 7.7 | 121.3 ± 35.1 | 32.2 ± 5.8 | 160.6 ± 29.1 | |
| X-X- (32) | 213.4 ± 35.6 | 44.2 ± 7.4 | 136.3 ± 38.1 | 32.9 ± 5.6 | 164.1 ± 28.1 | |
| P | 0.226 | 0.152 | 0.159 | 0.897 | 0.924 | |
| Pc | 0.678 | 0.456 | 0.477 | 1.000 | 1.000 | |
| APOB Ins/Del | II (30) | 210.0 ± 39.6 | 45.1 ± 7.6 | 130.3 ± 45.4 | 32.1 ± 7.1 | 160.3 ± 36.0 |
| ID (56) | 206.8 ± 31.9 | 47.0 ± 7.5 | 126.1 ± 33.2 | 33.7 ± 6.6 | 167.9 ± 32.7 | |
| DD (14) | 195.1 ± 13.7 | 46.6 ± 8.3 | 118.1 ± 17.3 | 30.4 ± 4.9 | 151.9 ± 25.2 | |
| P | 0.769 | 0.614 | 0.851 | 0.260 | 0.300 | |
| Pc | 1.000 | 1.000 | 1.000 | 0.780 | 0.900 | |
| LDLR AvaII | A+A+ (9) | 209.9 ± 29.2 | 46.6 ± 6.2 | 131.2 ± 36.0 | 32.1 ± 3.4 | 159.9 ± 17.4 |
| A+A- (25) | 211.2 ± 38.6 | 48.0 ± 7.5 | 129.2 ± 40.0 | 34.0 ± 8.9 | 169.8 ± 44.0 | |
| A-A- (16) | 203.3 ± 22.6 | 45.7 ± 6.9 | 122.9 ± 25.6 | 34.6 ± 5.6 | 173.1 ± 28.4 | |
| P | 0.960 | 0.499 | 0.943 | 0.556 | 0.540 | |
| Pc | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | |
| LDLRHincII | H+H+ (32) | 200.9 ± 27.5 | 44.3 ± 7.2 | 120.3 ± 33.8 | 33.8 ± 5.9 | 168.8 ± 29.8 |
| H+H- (55) | 203.6 ± 31.3 | 47.9 ± 7.8 | 124.0 ± 31.9 | 32.1 ± 7.3 | 160.2 ± 36.2 | |
| H-H- (13) | 229.4 ± 42.4 | 45.2 ± 7.1 | 150.3 ± 47.0 | 32.7 ± 5.1 | 163.6 ± 26.2 | |
| P | 0.095 | 0.102 | 0.119 | 0.265 | 0.259 | |
| Pc | 0.285 | 0.306 | 0.357 | 0.795 | 0.777 | |
Number of individuals between parentheses. TC, total cholesterol; HDL-c, high-density lipoprotein cholesterol; LDL-c, low-density lipoprotein cholesterol; VLDL-c, very low-density lipoprotein cholesterol; TG, triglycerides. +/- indicates the presence/absence of a restriction site. Ins/Del indicates insertion/deletion. Data are reported as mean±SD and compared by the Mann-Whitney test. Values for APOE genotypes were compared by the Kruskal-Wallis test. Pc, probabilities in reference to the Bonferroni correction.