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. Author manuscript; available in PMC: 2011 Feb 10.
Published in final edited form as: J Autoimmun. 2010 Nov 13;36(1):65–75. doi: 10.1016/j.jaut.2010.10.007

Figure 7.

Figure 7

IgG2b is the dominant anti-GPI isotype in mice transferred with Th17 polarized KRN T cells while IgG1 is dominant in mice transferred with naive T cells and KRN/T-bet−/− Th17 cells. Serum titers of individual isotypes of anti-GPI were measured every 7 days by ELISA using isotype-specific secondary antibodies. a, Antibody titers of 10 mice transferred with 9.5×106 Th17 polarized KRN T cells. Each symbol represents one mouse. b, Antibody titers of 9 mice transferred with 3.5×105 naive KRN T cells. c, Antibody titers of 13 mice transferred with 9.5×106 Th17 polarized T cells from KRN/T-bet−/− mice on day 14 post transfer. d, The thickness of both rear ankles was measured as an induction of arthritis in Balb/c mice transferred with Th17 serum or Th17 serum depleted of IgG1. e, Mice were examined for disease severity and given a clinical score of disease. Results are representative of 5 mice per group.