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. Author manuscript; available in PMC: 2011 Dec 10.
Published in final edited form as: Mol Cell. 2010 Dec 10;40(5):689–701. doi: 10.1016/j.molcel.2010.11.031

Figure 1. Coactivator and Corepressors are histone-modifying enzymes.

Figure 1

(A) The histone acetyltransferase, Gcn5, as part of the SAGA complex, is recruited to genes by a variety of transcriptional activators such as the sequence-specific binding protein Gal4. Acetylation of histone H3 through recruitment of Gcn5 by Gal4 synergizes with nucleosome remodeling activities leading to the recruitment of RNA Pol II. (B) The histone deacetylase HDAC1 can be recruited to genes as part of the SMRT/NCOR complexes by sequence-specific DNA-binding proteins such as Retinoic acid receptors (RXR/RAR). Deacetylation of histones facilitates reassembly of compact chromatin for transcriptional repression.