Table 4.

Association of Obesity Measures With LV Parameters by Sex After Adjustment for Risk Factors in MESA Participants With CMR (N = 5,004)

		Women		Men
LV Parameter	Obesity Measure	Slope (per 10-Unit Change in Obesity Measure)	p Value	Slope (per 10-Unit Change in Obesity Measure)	p Value	p Value for Sex Interaction
LV mass (g)	BMI range (kg/m2)
	<25	21.9	<0.001	44.2	<0.001	<0.001
	25–30	27.0	<0.001	26.1	<0.001
	>30	15.4	<0.001	27.6	<0.001
	FM (kg)	5.7	<0.001	6.9	<0.001	0.15
	LBM (kg)	19.1	<0.001	18.6	<0.001	0.36
	WHR*	48.3	<0.001	69.4	<0.001	<0.001
LV volume (ml)	BMI range (kg/m2)
	<25	21.7	<0.001	27.2	<0.001	0.35
	25–30	19.1	<0.001	13.0	0.001
	>30	13.4	<0.001	10.4	0.008
	FM (kg)	3.4	<0.001	−2.1	0.052	<0.001
	LBM (kg)	21.7	<0.001	23.9	<0.001	0.10
	WHR*	12.8	0.038	25.9	0.013	0.38
M/V ratio (g/ml)	BMI range (kg/m2)
	<25	0.01	0.997	0.10	0.024	<0.001
	25–30	0.05	0.051	0.08	0.021
	>30	0.01	0.497	0.09	0.004
	FM (kg)	0.02	<0.001	0.06	<0.001	<0.001
	LBM (kg)	−0.04	0.001	−0.07	<0.001	0.45
	WHR*	0.32	<0.001	0.33	<0.001	0.74
Ejection fraction (%)	BMI range (kg/m2)
	<25	0.2	0.88	2.2	0.11	0.80
	25–30	0.1	0.90	0.0	0.98
	>30	−1.0	0.06	−0.7	0.47
	FM (kg)	−1.0	0.46	0.4	0.14	0.28
	LBM (kg)	−0.4	0.34	−1.0	0.02	0.48
	WHR*	0.82	0.64	−0.97	0.70	0.20

^*Each slope corresponds to 1-unit change in WHR. All models are stratified by sex, and adjusted for age, race, systolic and diastolic blood pressures, use of antihypertensive medications, diabetes, cigarette smoking, total cholesterol, HDL, log triglycerides, use of lipid-lowering medication, family history of heart attack, heavy drinking, and intentional exercise in quartiles. Linear regression models examining associations between FM and LV parameters additionally adjusted for LBM.

LBM = lean body mass; M/V = mass to volume; other abbreviations as in Tables 1 and 2.