Table 1.

Summary of Cases of Occurrence of New Tumors after Radiotherapy for Benign Conditions

Ref	Patient (Age at Time of XRT [y] and Gender)	Primary Tumor	Initial Surgery	XRT*	Second Tumor	Time Elapsed from XRT (y)	Outcome
Adapted from Balasubramaniam et al.3 Ref, reference; XRT, radiotherapy; GBM, glioblastoma multiforme; GKS, gamma-knife surgery; NF2, neurofibromatosis 2; N/A, not available; VS, vestibular schwannoma; Translab, translabyrinthine; SFRT, stereotactic fractionated radiotherapy; mening, meningioma; dx, diagnosis; fx, fractions; VPS, ventriculoperitoneal shunt; ?, type of treatment and dose unknown; SOC, suboccipital craniotomy; MPNST, malignant peripheral nerve sheath tumor.
3	64 F	VS, NF2−	Translab	SFRT 50 Gy/25 fx	GBM	5	Died 4 mo later
19	63 F	Mening	No	GKS 40 Gy/20 Gy	GBM	7	N/A
20	57 F	VS, NF2−	No	GKS 27.5 Gy/11 Gy	GBM	7.5	N/A
21	14 M	AVM	VPS	GKS 40 Gy/20 Gy	GBM	7	Died 10 mo later
22	66 F	Cavernoma	No	GKS 20 Gy/10 Gy	GBM	13	N/A
23	N/A	VS, NF2+	N/A	Yes, ?	Malignant ependymoma	N/A	N/A
23	N/A	VS, NF2+	N/A	Yes, ?	Malignant mening	N/A	N/A
24	53 F	Mening	No	GKS×3, 60 Gy/30 Gy	Malignant osteosarcoma	4	N/A
25	41 M	Pituitary	Yes	Proton 87 Gy/25 fx	Benign mening	16	N/A
25	53 M	Pituitary	Yes	Proton 104 Gy/12 fx	VS	19	N/A
6	26 F	VS, NF2−	SOC	GKS 34 Gy/17 Gy	MPNST	6	Died 10 mo later
23	N/A	VS, NF2+	N/A	Yes, ?	MPNST	N/A	N/A
23	N/A	VS, NF2+	N/A	Yes, ?	MPNST	N/A	N/A
23	N/A	VS, NF2+	N/A	Yes, ?	MPNST	N/A	N/A
26	30 F	VS, NF2+	No	GKS ?/15 Gy	MPNST	4	Died 2 mo later
4	44 M	VS, NF2−	No	GKS 34 Gy/14.36 Gy	Triton	5	Died 1 y later
26	18 F	VS, NF2+	No	Yes, ? ?/20 Gy	Triton	6	N/A
27	20 F	VS, NF2+	No	GKS 20 Gy/10–15 Gy	Meningiosarcoma	6	Died 2 y later
28	23 M	VS, NF2+	No	GKS ?/15 Gy	Rapid regrowth	2	Died
5	56 F	VS, NF2−	Yes	GKS ?/15 Gy	Rapid regrowth	0.5	Died 1 y later

^*For gamma-knife surgery treatment, central dose and peripheral dose are reported as: central dose Gy/peripheral dose Gy.