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. 2010 Dec 15;152(2):618–628. doi: 10.1210/en.2010-0823

Fig. 2.

Fig. 2.

Metformin has minimal effects on metabolic parameters in PNA mice. A, Average daily food intake per unit body mass was similar in PNA and CON mice and unaffected by metformin (met) (n = 11–12 per group). Arrow indicates start of metformin administration to treated groups. B, Body mass was unaffected by metformin (n = 11–12 per group). Arrow indicates start of treatment. C, Ratio of parametrial fat pad mass to body mass was not different among groups (n = 21–24 per group). D, Blood glucose levels in random-fed (n = 21–24 per group) and fasted (n = 10 per group) mice. Metformin significantly decreased fasting blood glucose in PNA mice. E, GTT indicated no difference in glucose tolerance among groups (n = 10 per group). F, ITT showed no differences in insulin sensitivity (n = 10 per group). *, P < 0.05. ns, Not significant. ITT curves from untreated CON and PNA mice were generated from data reported previously (10).