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. 2010 Dec 15;152(2):618–628. doi: 10.1210/en.2010-0823

Fig. 4.

Fig. 4.

GnRH neurons from PNA mice have increased firing activity that is reversed by metformin. A, Representative graphs of firing rate over time in GnRH neurons from mice from each group. Events are binned in 60-sec intervals. B, Firing rate of GnRH neurons was higher in PNA mice (n = 17 cells from 10 mice) compared with CON (n = 17 cells from eight mice). Firing rate was lower in GnRH neurons from PNA mice treated with metformin (met) (n = 14 cells from seven mice) but was not different in cells from CON mice on metformin (n = 19 cells from eight mice). Percent quiescence (C) and maximum duration of quiescence (D) were lower in GnRH neurons from PNA mice not treated with metformin. Metformin restored quiescence measures of GnRH neurons from PNA mice but had no effect on CON mice. Quiescence is defined as 0–1 events/min. Different lowercase letters indicate groups with significantly different means. P < 0.05.