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. 2010 Dec 15;152(2):618–628. doi: 10.1210/en.2010-0823

Fig. 5.

Fig. 5.

An AMPK antagonist stimulates firing in metformin-treated but not untreated mice. A, Representative plots of firing rate over time from each group. Black bar indicates time of CC application. CC induces an acute increase in firing in GnRH neurons from metformin (met)-treated mice. B, Percent of cells responding with a greater than 20% increase in firing rate in response to CC application. Significantly more cells from metformin-treated compared with untreated mice responded to the antagonist (P < 0.05). C, Mean percent change in firing rate in response to CC application (CON, n = 10 cells from five mice; PNA, n = 8 cells from three mice; CON metformin, n = 10 cells from four mice; and PNA metformin, n = 11 cells from five mice). Different lowercase letters indicate groups with significantly different means. P < 0.05.