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RSV infection reduces GR-DNA binding. A549 cells were mock inoculated with HeLa-conditioned media (black bar) or inoculated with live rgRSV (white bar) (MOI = 3) for 1 h followed by treatment with 100 nm dexamethasone for 5 h. Cells were fixed and ChIP performed using an antibody specific to GR or nonspecific immune serum (NIS). GR binding to the GILZ (A), FKBP51 (B), and MKP-1 (C) promoters was determined by real-time PCR. A threshold of 0.1 was used. Means and sd are shown (n = 3).
