Table 2.

Biomechanical parameters of the load–distension curves of 3-month-old WT, 17-month-old WT mice, and 17-month-old LOXL1^−/−demonstrating decrease in ultimate load at failure in LOXL1^−/−mice relative to WT mice, independent of age

Categories of mice	Ultimate load at failure (N)	Linear stiffness (N/mm)	Maximal distension (mm)	Energy absorbed (N–mm)
3-month-old WT (n=10)	2.78±0.20a	1.18±0.15	6.83 ±1.05	9.23 ±2.04
17-month-old WT (n=6)	2.61±0.36	1.12±0.11	5.15±0.81	6.33±1.08
LOXL1−/− (n=5)	1.91±0.50	1.20±0.17	7.18±2.68	7.71±4.19
*p values
3-month-old WT vs. 17-month-old WT	0.72	0.82	0.14	0.11
3-month-old WT vs. L0XL1−/−	0.001	0.99	0.97	0.63
17-month-old WT vs. LOXL1−/−	0.008	0.75	0.12	0.76

^*p values are generated from post hoc pairwise comparisons using Sidak's multiple comparisons procedure

^aData are presented as mean±standard deviation