Table 3.

Biomechanical parameters of the load−distension curves of 3-month-old WT, LOXL1^−/−, and 3-month-old WT mice after disruption of specific levels of support, demonstrating decrease in ultimate load at failure in WT mice with disrupted levels of support similar to LOXL1^−/−mice

Categories of mice	Ultimate load at failure (N)	Linear stiffness (N/mm)	Maximal distension (mm)	Energy absorbed (N–mm)
WT (n=10)	2.78±0.20	1.18±0.15	6.83±1.05	9.23±2.04
LOXL1−/− (n=5)	1.91±0.50	1.20±0.17	7.18±2.68	7.71±4.19
WT without level I (n=4)	2.37±0.28	1.17±0.10	6.56±1.24	8.32±1.59
WT without level II (n=4)	2.82±0.61	1.17±0.20	6.95±0.42	9.52±1.49
WT without levels I and II (n=4)	1.85±0.25	1.24±0.29	4.88±1.30	5.11±1.93
p values
WT vs. LOXL1−/−	0.001	>0.99	0.99	0.68
WT vs. WT without level I	0.23	>0.99	>0.99	0.94
WT vs. WT without level II	>0.99	>0.99	>0.99	>0.99
WT vs. WT without levels I and II	0.001	0.97	0.13	0.04
LOXL1−/− vs. WT without level I	0.32	0.99	0.92	0.98
LOXL1−/− vs. WT without level II	0.02	0.99	0.99	0.65
LOXL1−/− vs. WT without levels I and I	>0.99	0.99	0.17	0.39

Data are presented as mean+standard deviation, p values are generated from post hoc pairwise comparisons between WT and all other groups were made using Dunnett's multiple comparisons procedure. Similar analysis performed excluding WT and comparing all groups to LOXL1^−/−