Table 6A.
Means (Standard Deviation) of Clinical Measures: Parents' Ratings
| |
Baseline |
Week 8 |
Week 10 |
Week 13 |
Week 21a |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Measure | Placebo | Zinc_1 | Zinc_2 | Placebo | Zinc_1 | Zinc_2 | Placebo | Zinc_1 | Zinc_2 | Placebo | Zinc_1 | Zinc_2 | Placebo | Zinc_1 | Zinc_2 |
| SNAP 9 DSM-IV inattentive Sx | 2.38 (0.54) | 2.39 (0.39) | 2.17 (0.58) | 2.12 (0.55) | 2.00 (0.58) | 1.85 (0.77) | 1.68 (0.51) | 1.73 (0.74) | 1.40 (0.68) | 1.23 (0.38) | 1.32 (0.7) | 0.97 (0.64) | 0.98 (0.47) | 1.14 (0.76) | 0.73 (0.43) |
| SNAP 9 DSM-IV hyperactive-imp. Sx | 1.95 (0.71) | 2.13 (0.65) | 1.38 (1.13) | 1.69 (0.83) | 1.84 (0.66) | 1.08 (1.08) | 1.26 (0.71) | 1.49 (0.53) | 1.11 (0.88) | 0.79 (0.55) | 1.06 (0.6) | 0.36 (0.61) | 0.67 (0.52) | 0.85 (0.48) | 0.62 (0.98) |
| SNAP All 18 DSM-IV ADHD symptoms | 2.14 (0.52) | 2.15 (0.46) | 1.66 (0.57) | 1.90 (0.63) | 1.92 (0.54) | 1.47 (0.65) | 1.47 (0.51) | 1.61 (0.52) | 1.26 (0.62) | 1.01 (0.38) | 1.19 (0.56) | 0.67 (0.38) | 0.82 (0.44) | 0.99 (0.52) | 0.67 (0.56) |
| SNAP ODD DSM-IV symptoms | 1.33 (0.59) | 1.63 (0.67) | 1.12 (0) | 1.11 (0.63) | 1.49 (0.78) | 1.02 (0.81) | 0.92 (0.7) | 1.22 (0.73) | 0.80 (0.55) | 0.60 (0.41) | 0.87 (0.79) | 0.63 (0.32) | 0.49 (0.36) | 0.85 (0.77) | 0.75 (0.96) |
| Conners parent rating scale | |||||||||||||||
| Overall | 107.83 (31.9) | 115.85 (30.16) | 93.13 (34.53) | 95.54 (28.16) | 104.95 (33.46) | 78.63 (40.09) | 65 (28.35) | 81 (28.75) | 61.63 (36.67) | 49.09 (27.47) | 59.61 (26.95) | 41.63 (19.68) | 39.74 (28.44) | 52.95 (32.19) | 35.43 (28.91) |
| Global index | 1.61 (0.52) | 1.71 (0.4) | 1.60 (0.78) | 1.47 (0.55) | 1.62 (0.5) | 1.25 (0.68) | 1.00 (0.53) | 1.35 (0.42) | 1.03 (0.64) | 0.77 (0.45) | 0.97 (0.44) | 0.68 (0.6) | 0.61 (0.49) | 0.76 (0.58) | 0.76 (0.57) |
| Oppositional | 1.05 (0.61) | 1.28 (0.64) | 1.44 (0.79) | 1.01 (0.51) | 1.20 (0.54) | 1.3 (0.86) | 0.73 (0.61) | 1.09 (0.56) | 0.97 (0.69) | 0.58 (0.41) | 0.74 (0.5) | 0.76 (0.71) | 0.48 (0.34) | 0.61 (0.57) | 0.85 (0.88) |
| Cognitive problems | 2.17 (0.41) | 1.98 (0.47) | 2.18 (0.58) | 1.97 (0.49) | 1.92 (0.74) | 1.90 (0.64) | 1.35 (0.57) | 1.50 0(0.74) | 1.32 (0.82) | 1.01 (0.47) | 1.15 (0.52) | 1.03 (0.71) | 0.82 (0.56) | 0.89 (0.7) | 0.95 (0.7) |
| Hyperactive | 1.55 (0.74) | 1.65 (0.7) | 1.48 (0.97) | 1.40 (0.74) | 1.56 (0.62) | 1.15 (0.92) | 0.88 (0.6) | 1.22 (0.61) | 0.97 (0.85) | 0.61 (0.55) | 0.83 (0.48) | 0.50 (0.58) | 0.49 (0.49) | 0.68 (0.48) | 0.58 (0.71) |
| Anxious shy | 0.41 (0.53) | 0.34 (0.38) | 0.56 (0.65) | 0.32 (0.49) | 0.26 (0.2) | 0.45 (0.77) | 0.15 (0.25) | 0.14 (0.11) | 0.29 (0.44) | 0.09 (0.2) | 0.07 (0.1) | 0.29 (0.45) | 0.08 (0.14) | 0.08 (0.15) | 0.13 (0.21) |
| Perfectionistics | 0.50 (0.51) | 0.65 (0.48) | 0.49 (0.53) | 0.38 (0.41) | 0.57 (0.42) | 0.40 (0.5) | 0.31 (0.37) | 0.52 (0.31) | 0.32 (0.46) | 0.27 (0.42) | 0.30 (0.24) | 0.11 (0.19) | 0.19 (0.32) | 0.31 (0.28) | 0.19 (0.29) |
| Social problems | 0.43 (0.58) | 0.71 (0.74) | 0.48 (0.32) | 0.28 (0.36) | 0.55 (0.6) | 0.39 (0.31) | 0.17 (0.25) | 0.38 (0.65) | 0.29 (0.37) | 0.13 (0.24) | 0.26 (0.57) | 0.20 (0.32) | 0.11 (0.23) | 0.22 (0.4) | 0.17 (0.24) |
| Psychosomatic | 0.63 (0.65) | 0.37 (0.38) | 0.59 (0.58) | 0.56 (0.6) | 0.32 (0.38) | 0.35 (0.36) | 0.31 (0.39) | 0.19 (0.31) | 0.19 (0.29) | 0.30 (0.39) | 0.19 (0.23) | 0.15 (0.16) | 0.26 (0.38) | 0.18 (0.34) | 0.11 (0.2) |
| ADHD index | 2.26 (0.49) | 2.17 (0.44) | 2.19 (0.46) | 2.05 (0.53) | 2.11 (0.55) | 1.90 (0.67) | 1.35 (0.55) | 1.63 (0.58) | 1.33 (0.62) | 1.00 (0.49) | 1.25 (0.51) | 1.04 (0.71) | 0.82 (0.64) | 0.97 (0.56) | 1.04 (0.71) |
| Restless/impulsive | 1.89 (0.58) | 2.08 (0.51) | 1.70 (0.85) | 1.70 (0.65) | 1.93 (0.49) | 1.42 (0.73) | 1.17 (0.61) | 1.50 (0.49) | 1.15 (0.7) | 0.83 (0.52) | 1.14 (0.54) | 0.73 (0.68) | 0.68 (0.58) | 0.88 (0.62) | 0.77 (0.55) |
| Emotional lability | 0.93 (0.72) | 0.83 (0.52) | 1.27 (0.87) | 0.92 (0.73) | 0.92 (0.71) | 0.90 (0.79) | 0.64 (0.59) | 1.00 (0.7) | 0.79 (0.67) | 0.57 (0.52) | 0.56 (0.52) | 0.59 (0.58) | 0.43 (0.41) | 0.49 (0.55) | 0.67 (0.69) |
| 9 DSM-IV Inattentive Sx | 2.38 (0.51) | 2.15 (0.51) | 2.16 (0.63) | 2.13 (0.5) | 2.03 (0.63) | 1.90 (0.75) | 1.48 (0.58) | 1.64 (0.65) | 1.29 (0.9) | 1.11 (0.43) | 1.17 (0.48) | 1.13 (0.84) | 0.88 (0.56) | 0.88 (0.6) | 0.97 (0.75) |
| 9 DSM-IV hyperactive-imp. Sx | 1.70 (0.72) | 1.77 (0.78) | 1.53 (1.02) | 1.56 (0.79) | 1.82 (0.54) | 1.34 (1.00) | 1.00 (0.61) | 1.41 (0.64) | 1.13 (0.81) | 0.72 (0.55) | 0.98 (0.54) | 0.50 (0.6) | 0.57 (0.57) | 0.79 (0.52) | 0.63 (0.67) |
| All 18 DSM-IV symptoms | 2.04 (0.55) | 1.96 (0.54) | 1.84 (0.63) | 1.84 (0.56) | 1.93 (0.49) | 1.62 (0.73) | 1.24 (0.5) | 1.52 (0.52) | 1.21 (0.75) | 0.91 (0.43) | 1.08 (0.45) | 0.81 (0.58) | 0.72 (0.52) | 0.83 (0.47) | 0.80 (0.59) |
| CDI | |||||||||||||||
| CDI by parent | 21.58 (4.84) | 22.4 (6.11) | 18.38 (2.2) | 19.83 (4.02) | 19.00 (4.38) | 16.5 (3.74) | 18.09 (3.29) | 17.89 (4.57) | 16.13 (3.72) | 17.17 (2.62) | 18.06 (4.65) | 14.88 (2.8) | 16.77 (2.93) | 16.63 (3.29) | 16.14 (5.76) |
| CDI by child | 25.75 (3.57) | 25.35 (3.8) | 28.00 (6.68) | 26.71 (3.57) | 26.26 (3.62) | 30.00 (6.87) | 25.13 (2.2) | 27.11 (4.16) | 30.63 (8.94) | 24.30 (4.72) | 26.72 (3.36) | 28.63 (7.58) | 26.55 (4.5) | 27.00 (3.54) | 29.29 (7.39) |
a
At week 21, “Placebo” means 13 weeks of placebo and 8 weeks of zinc compared with 21 weeks of zinc for the others.
Zinc_1 = 15 mg zinc in the morning; Zinc_2 = 15 mg zinc two times per day.
CDI = children's depression inventory; AHDH = attention-deficit/hyperactivity disorder; DMS-IV = Diagnostic and Statistical Manual fourth edition; ODD = oppositional defiant disorder; SNAP = Swanson, Nolan, and Pelham rating; Sx = symptoms.