Table 6B.
Means (Standard Deviation) of Clinical Measures: Teacher's Rating
| |
Baseline |
Week 8 |
Week 10 |
Week 13 |
Week 21a |
|||||
|---|---|---|---|---|---|---|---|---|---|---|
| Mean (SD)/time | Placebo | Zinc | Placebo | Zinc | Placebo | Zinc | Placebo | Zinc | Placebo | Zinc |
| SNAP 9 DSM-IV inattentive Sx | 2.35 (0.51) | 2.26 (0.57) | 2.03 (0.79) | 2.16 (0.73) | 1.64 (0.66) | 1.61 (0.75) | 1.07 (0.59) | 1.20 (0.57) | 1.10 (0.55) | 1.51 (0.65) |
| SNAP 9 DSM-IV hyperactive-imp. Sx | 1.78 (0.89) | 1.78 (0.7) | 1.57 (1.02) | 1.73 (0.75) | 1.36 (0.89) | 1.2 (0.7) | 0.66 (0.80) | 0.93 (0.62) | 0.78 (0.74) | 1.04 (0.48) |
| SNAP All 18 DSM-IV ADHD Sx | 2.07 (0.59) | 2.02 (0.41) | 1.80 (0.78) | 1.95 (0.52) | 1.50 (0.69) | 1.41 (0.6) | 0.87 (0.58) | 1.07 (0.53) | 0.94 (0.59) | 1.27 (0.47) |
| SNAP DSM-IV ODD symptoms | 0.71 (0.76) | 1.27 (0.94) | 0.7 (0.71) | 1.2 (0.98) | 0.51 (0.61) | 0.76 (0.75) | 0.32 (0.40) | 0.85 (0.67) | 0.44 (0.45) | 0.71 (0.64) |
| Conners Teacher Rating Total and Factors | ||||||||||
| Overall | 82.82 (24.89) | 91.65 (23.05) | 74.64 (29.50) | 85.41 (28.48) | 57.5 (29.41) | 60.42 (27.77) | 31.83 (23.46) | 53.63 (29.44) | 40.45 (30.94) | 57.57 (25.35) |
| Global index | 0.88 (0.38) | 1.05 (0.4) | 0.78 (0.36) | 0.99 (0.47) | 0.63 (0.39) | 0.83 (0.46) | 0.43 (0.50) | 0.83 (0.64) | 0.45 (0.42) | 0.80 (0.49) |
| Oppositional | 1.77 (0.50) | 1.81 (0.64) | 1.67 (0.66) | 1.68 (0.75) | 1.18 (0.73) | 0.98 (0.64) | 0.67 (0.49) | 0.85 (0.67) | 0.79 (0.64) | 0.98 (0.53) |
| Cognitive problems | 1.82 (0.64) | 1.95 (0.48) | 1.67 (0.85) | 1.88 (0.63) | 1.37 (0.79) | 1.31 (0.56) | 0.72 (0.58) | 0.98 (0.59) | 0.80 (0.71) | 1.19 (0.60) |
| Hyperactive | 1.74 (0.65) | 1.84 (0.55) | 1.49 (0.7) | 1.8 (0.73) | 1.26 (0.76) | 1.23 (0.55) | 0.63 (0.40) | 0.89 (0.64) | 1.03 (0.64) | 1.09 (0.64) |
| Anxious shy | 1.13 (0.43) | 1.19 (0.47) | 0.95 (0.56) | 1.02 (0.49) | 0.76 (0.52) | 0.79 (0.44) | 0.35 (0.47) | 0.91 (0.59) | 0.53 (0.53) | 0.85 (0.39) |
| Perfectionistism | 0.25 (0.48) | 0.42 (0.56) | 0.32 (0.7) | 0.39 (0.58) | 0.05 (0.15) | 0.37 (0.47) | 0.25 (0.58) | 0.44 (0.44) | 0.27 (0.34) | 0.29 (0.32) |
| Social problems | 1.23 (0.65) | 1.29 (0.55) | 1.02 (0.52) | 1.32 (0.65) | 0.68 (0.57) | 0.92 (0.58) | 0.50 (0.37) | 0.94 (0.48) | 0.64 (0.60) | 1.04 (0.50) |
| ADHD index | 1.76 (0.50) | 1.75 (0.41) | 1.60 (0.65) | 1.68 (0.46) | 1.27 (0.66) | 1.24 (0.59) | 0.67 (0.56) | 0.99 (0.42) | 0.82 (0.79) | 1.04 (0.43) |
| Restless/impulsive | 0.39 (0.51) | 0.62 (0.55) | 0.3 (0.43) | 0.68 (0.73) | 0.18 (0.34) | 0.61 (0.57) | 0.21 (0.45) | 0.56 (0.66) | 0.20 (0.35) | 0.46 (0.66) |
| Emotional lability | 1.36 (0.47) | 1.48 (0.44) | 1.27 (0.43) | 1.30 (0.43) | 1.08 (0.63) | 1.05 (0.5) | 0.63 (0.64) | 1.09 (0.69) | 0.70 (0.59) | 1.14 (0.5) |
| 9 DSM IV inattentative Sx | 1.90 (0.84) | 2.03 (0.54) | 1.83 (0.92) | 2.01 (0.73) | 1.47 (0.90) | 1.22 (0.7) | 0.62 (0.78) | 0.94 (0.75) | 0.83 (0.76) | 1.30 (0.56) |
| 9 DSM IV hyperactive-imp. Sx | 1.86 (0.63) | 1.85 (0.54) | 1.61 (0.72) | 1.81 (0.7) | 1.34 (0.78) | 1.24 (0.53) | 0.64 (0.45) | 0.86 (0.61) | 1.06 (0.68) | 1.06 (0.59) |
| All 18 DSM IV symptoms | 1.88 (0.69) | 1.93 (0.5) | 1.71 (0.79) | 1.90 (0.67) | 1.40 (0.81) | 1.23 (0.58) | 0.63 (0.58) | 0.90 (0.65) | 0.94 (0.69) | 1.17 (0.53) |
a
At week 21, “Placebo” means 13 weeks of placebo and 8 weeks of zinc compared with 21 weeks of zinc for the others.
Because the interim analysis suggested that the morning dose of zinc was responsible for effects rated by teachers and we did not expect an effect on teacher ratings from the afternoon dose, and because so many teacher ratings were missing because of vacations, the two zinc dosing schedules (morning only and two times per day) were collapsed for teacher ratings.
AHDH = attention-deficit/hyperactivity disorder; DMS-IV = Diagnostic and Statistical Manual fourth edition; ODD = oppositional defiant disorder; SNAP = Swanson, Nolan, and Pelham rating; Sx = symptoms.