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Kaplan-Meier overall survival curves in all analysed osteosarcoma patients according to nuclear area and coefficient of nuclear roundness (CRN) of tumour cells (large and round nuclei: ≥ 42.5 μm2 + CRN ≥0.7; small and ovoid/spindle-shaped nuclei: < 42.5 μm2 + CRN < 0.7). Patients with large and round nuclei had better prognosis.
