Table 1.

Distribution of clinicopathological parameters and cross-tabulations with nuclear area and coefficient of nuclear roundness (CNR)

		Nuclear Area			Nuclear Area and CNR
Variable	No. of cases	Small nuclei	Large nuclei	P-value	Small and ovoid/spindleshaped nuclei	Large and round nuclei	P-value
Roundness coefficient
round nuclei	23	13	10	.00	-	-	-
non- round nuclei	33	29	4		-	-
Necrosis grade
Poor responders	40	34	6	.00	36	4	.01
Good responders	16	8	8		10	6
Tumor size
< 12 cm	25	17	8	.27	19	6	.28
>12cm	31	25	6		27	4
Local recurrence
Yes	33	22	11	.08	26	7	.43
No	23	20	3		20	3
Metastasis at diagnosis
Yes	26	22	4	.12	24	2	.06
No	30	20	10		22	8
Death
Yes	26	17	9	.12	27	3	.09
No	30	25	5		19	7