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. Author manuscript; available in PMC: 2012 Jan 1.

Published in final edited form as: Nanomedicine (Lond). 2011 Jan;6(1):25–42. doi: 10.2217/nnm.10.129

Table 3.

Cytotoxicity of catalase nanozymes (Z=1) in vitro

Formulation	IC₅₀, mg/ml ^a
Formulation	BMM	BBMEC	CATH.a
PEI₅₀	0.4 ± 0.1	> 3 ± 0.1	1.7 ± 0.1
PEI₅₀-PEG	2 ± 0.1	> 3 ± 0.1	> 3 ± 0.1
PL₁₀-PEG	0.4 ± 0.07	1 ± 0.1	0.3 ± 0.05
PL₃₀-PEG	0.02 ± 0.03	0.2 ± 0.02	0.045 ± 0.09
PL₅₀-PEG	0.01 ± 0.05	0.15 ± 0.02	0.03 ± 0.06
EPL	2 ± 0.1	> 3 ± 0.1	1.5 ± 0.1
PGLU₅₀-PEG	2 ± 0.2	> 5 ± 0.1	1 ± 0.1
PEI₅₀/catalase	0.7 ± 0.2	> 3 ± 0.1	2 ± 0.1
PEI₅₀-PEG/catalase	>3 ± 0.05	> 3 ± 0.1	> 3 ± 0.1
PL₁₀-PEG/catalase	0.5 ± 0.07	2 ± 0.1	0.4 ± 0.01
PL₃₀-PEG/catalase	0.04 ± 0.001	0.18 ± 0.02	0.06 ± 0.001
PL₅₀-PEG/catalase	0.03 ± 0.001	0.2 ± 0.05	0.02 ± 0.001
EPL/catalase	0.2 ± 0.05	> 3 ± 0.1	0.9 ± 0.1
PGLU₅₀-PEG/catalase	> 5 ± 0.1	> 5 ± 0.2	> 3 ± 0.2

^a

The IC₅₀ values refer to polymer concentration in treatment solutions. No toxicity of catalase alone was observed at concentrations up to 6 mg/ml.