Table 4.
Loading of catalase nanozymes into BMMa in serum-free media
| Z ratio | Polymer | ||||||
|---|---|---|---|---|---|---|---|
| PEI50 | PEI50-PEG | PL10-PEG | PL30-PEG | PL50-PEG | EPL | PGLU50-PEG | |
| 0.5 | 123 ± 2 (**) | 100 ± 5 (ns) | 99 ± 4 (ns) | 87 ± 2 (*) | 81 ± 2 (*) | 115.5 ± 2 (**) | 100.1 ± 2 (ns) |
| 1 | 120 ± 2 (*) | 85 ± 3 (*) | 58± 4 (*) | 79 ± 1 (*) | 34 ± 4 (**) | 112.2 ± 1 (*) | 100.2 ± 3 (ns) |
| 2 | 110 ± 2 (ns) | 73 ± 2 (*) | 51 ± 2 (**) | 72 ± 2 (*) | 20 ± 4 (**) | 117.5 ± 2 (**) | 87.1 ± 3 (*) |
| 5 | 113 ± 1 (*) | 73 ± 3 (*) | 42 ± 2 (**) | 45 ± 2 (**) | 21± 3 (**) | 116.0 ± 1 (**) | 78.6 ± 1 (*) |
| 10 | 110 ± 2 (ns) | 75 ± 1 (*) | n/db | n/db | n/db | 100.9 ± 2 (ns) | 79 ± 1 (*) |
| 20 | 66 ± 1 (**) | 68 ± 2 (*) | n/db | n/db | n/db | 111.4 ± 3 (*) | 73 ± 2 (*) |
a
Loading is expressed as a % of nanozyme vs. catalase alone accumulation levels
b
Nanozymes with high Z ratios were not examined due to their toxicity to BMM
Statistical significance is shown by symbols: p<0.005 (¶), p<0.05 (§), and non-significant (#) compared with accumulation levels of catalase alone at the same time point.