. Author manuscript; available in PMC: 2011 Dec 1.

Published in final edited form as: Proteomics. 2010 Dec;10(23):4163–4171. doi: 10.1002/pmic.201000229

Table 2.

Odds ratio of optimal codon usage between aggregation-prone and non-aggregation-prone sites for each amino acid

AA	E. coli	S. cerevisiae	D. melanogaster	M. musculus
Ala	0.99	0.99	1.43^***	–
Arg	1.11^(*)	1.06	1.37^***	1.26^***
Asn	1.10^*^()	1.05^^()	1.20^***	1.10^***
Asp	1.09^**	0.98	1.31^***	1.17^***
Cys	1.04	0.94^(*)	1.17^***	–
Gln	1.04	1.04	0.95	1.13^***
Glu	1.06	1.00	1.01	1.02
Gly	1.24^***	1.10^***	1.20^***	1.20^***
His	1.18^***	1.04	1.34^***	1.10^***
Ile	1.07^***	1.03	1.08^***	1.14^***
Leu	0.98	1.00	1.05^**	0.91^***
Lys	–	0.90^***	0.94	0.99
Phe	1.03	1.02	1.06^**	1.15^***
Pro	1.10	1.20	1.71^***	0.89^*
Ser	1.17^***	1.10^***	1.20^***	1.23^***
Thr	1.29^***	1.06^***	1.35^***	1.19^***
Tyr	1.22^***	1.03	1.18^***	–
Val	0.86^***	1.08^***	1.04^*	0.96^***
Overall	1.07^***	1.03^***	1.17^***	1.08^***

Note. —AA: amino acid; -: no optimal codon. Significance levels:

^***

P < 0.001;

^**

P < 0.01;

P < 0.05.

Significance levels in parentheses disappear after correction for multiple testing.