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Isoforms of tau and tau constructs used. The shortest isoform (0N3R) lacks two N-terminal exons (shown in pale grey in 2N4R) and the second of the microtubule binding repeats (dark grey) due to alternative splicing. Tau-NT and Tau-CT represent the N-terminal and C-terminal halves of 0N4R tau. The numbering of residues in all constructs used is that of the 2N4R isoform of human tau.
