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. 2011 Feb 10;7(2):e1001274. doi: 10.1371/journal.ppat.1001274

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Satou et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) BrdU was injected into mice twice a day for three days, and splenocytes were stained with antibodies to BrdU, CD4, CD8, and B220. (B) Incidence of T-cell lymphoma in HBZ-Tg mice was statistically significant compared with that in non-Tg mice (P<0.001 by the logrank test). (C) Pleomorphic lymphoma in the cervical lymph node in a representative HBZ-Tg mouse. Infiltrations of lymphoma cells into lung, bone marrow, spleen and liver are also shown. (D) Expression of CD3 and CD4 in lymphoma cells was shown by immunohistochemical staining. (E) Immunohistochemical staining for Foxp3 in primary lymphomas of HBZ-Tg mice.